The First Mechanical Thrombectomy Device Indicated for Pulmonary Embolism
The FlowTriever is an over-the-wire system designed to:
| Remove clot through both mechanical and aspiration mechanisms of action
| Capture and remove large clot burden from big vessels
| Treat in a single session
| Eliminate the need for thrombolytics
| Eliminate ICU Stay
Triever Aspiration Catheter - New Gen.4 Trievers
The Triever Aspiration Catheters feature a highly trackable, large lumen catheter, and large bore syringe designed to rapidly extract large volumes of clot while limiting blood loss when used in conjunction with the FlowSaver.
Available in 3 sizes:
- Triever16: 16 French
- Triever20: 20 French
- Triever24: 24 French
New Gen.4 Trievers
Advancements have been made to the Triever24 and Triever20 Catheters to enhance trackability and support, aspiration flow rate*, and ease of use.
- Enhanced trackability and support to navigate tortuous anatomy.
- Increased aspiration in Triever24 Catheter to maximize thrombus removal with ~20% cc/sec more than previous generation*
- Improved ease of use through new dilator twist lock, tapered dilator tip and more durable hemostasis valve.
Gen.4 Triever sizes: 20 & 24 French.
*Data on file.
The Triever20 Curve™ is a fully braided large bore catheter with a customizable 260⁰ bend designed for improved navigability & torqueability for challenging anatomies such as the left PA rainbow, TA, IVC and CIT in RA.
- Telescopic Steerability for targeted aspiration: Customizable angled tip for precise catheter placement by telescoping through the Triever24
- 260⁰ directionality range for improved navigation: Increased utility in challenging anatomies (RA, PA, IVC)
- One Price, One Patient, Many Choices: Triever20 Curve™ is included in the FlowTriever Per Procedure Pricing to use complimentarily with any FlowTriever products.
Triever24 with FLEX Technology
The Triever24 with FLEX technology provides increased flexibility through its softer durometer jacket, featuring a highly trackable, large lumen catheter, and large bore syringe designed to rapidly extract large volumes of clot while limiting blood loss when used in conjunction with the FlowSaver.
- 41% More Flexible than existing Triever24 catheter*
- Superior Trackability to better navigate tortuous anatomies and smoothly deliver the catheter to the left PA and through dilated right hearts
- Effective Aspiration to enhance Whoosh™ technique aspiration for maximum clot removal
Intri24 Introducer Sheath
The Intri24™ is purpose built, simplified and optimized forlarge bore venous access.
Large Bore Venous Access. Optimized.
• Tailored Profile for Large-Bore Access: Long, atraumatic tip dilator with proximal locking hub compatible with 0.035” guidewire.
• Seamless Delivery and Advancement: 33cm hydrophilic coated shaft designed to reduce friction upon insertion with a radiopaque markerbandfor visibility.
• Simplified Control: Single-handed hemostasis valve operation for minimal blood loss during insertion and removal of wires and catheters
FlowTriever Gen 1
The FlowTriever 2 catheter technology features a new disk shape designed to capture and remove acute to chronic clot.
- Laser cut element with proximal open cell design for optimized clot clearance
- New disk shape designed to disrupt clot, improving effectiveness of aspiration
- Increased usable length (120 cm) for more distal treatment
- 52% shorter deployment length
- Versatile sizing to treat vessels 6-16 mm in diameter
*The FlowTriever2 Catheter is not indicated for the treatment of pulmonary embolism
Blood Return System
Enabling Bloodless Thrombectomy for Pulmonary Embolism
The FlowSaver™ is designed to be used with the FlowTriever System to reduce blood loss by filtering aspirated thrombi and blood for reinfusion back to the patient, thus enabling bloodless thrombectomy for pulmonary embolism (PE) procedures.
The FlowSaver is compatible with Triever Catheters and includes a 40 micron filtration system, a clot reservoir, and a 60cc collection syringe. The accessible filtration design allows for clot examination and reservoir cleaning for more filtrations. Filtered blood can be reintroduced using a standard luer lock with the 60cc collection syringe.
Indications For Use:
The FlowTriever® system is indicated for: (1) the non-surgical removal of emboli and thrombi from blood vessels; and (2) injection, infusion and/or aspiration of contrast media and other fluids into or from a blood vessel. The FlowTriever system is intended for use in the peripheral vasculature and for the treatment of pulmonary embolism.Triever catheters are indicated for: (1) the non-surgical removal of emboli and thrombi from blood vessels; and (2) injection, infusion and/or aspiration of contrast media and other fluids into or from a blood vessel. Triever catheters are intended for use in the peripheral vasculature and for the treatment of pulmonary embolism. The Triever20 Curve is used coaxially within the Triever24 for: (1) The non-surgical removal of emboli and thrombi from vessels (2) Injection, infusion, and/or aspiration of contrast media and other fluids into or from a blood vessel: The Triever20 Curve is intended for use in the peripheral vasculature and for the treatment of pulmonary embolism. The Triever20 Curve is not indicated for use with FlowTriever Catheters.
Triever catheters are also intended for use in treating clot in transit in the right atrium, but not in conjunction with FlowTriever Catheters.
The Triever20 Curve must be used within the Triever24.The FlowTriever2® catheter is indicated for: (1) the non-surgical removal of emboli and thrombi from blood vessels; and (2) injection, infusion and/or aspiration of contrast media and other fluids into or from a blood vessel. The FlowTriever2® catheter is intended for use in the peripheral vasculature.The FlowSaver® blood return system is used with Triever catheters for autologous blood transfusion.See Instructions for Use for complete Indications for Use, contraindications, warnings, and precautions.
Caution: Federal (USA) law restricts this device to sale by or on the order of a physician.
Inari Medical, the Inari logo, FlowTriever, Triever, FlowTriever2, and FlowSaver are trademarks or service marks of Inari Medical.
All other trademarks or service marks are the property of their respective owners.
Pre FlowTriever PA-gram
Post FlowTriever PA-gram
“The FlowTriever System represents a valuable new option in the interventional toolbox for effectively treating PE.” (EV Today, Mar. 2019 issue)
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|2||Jaber WA, Fong PP, Weisz G, et al. Acute pulmonary embolism with an emphasis on an interventional approach. JACC 2016;67(8):991-1002.||Case Report|
|3||Chauhan CA, Scolieri SK, Toma C. Percutaneous pulmonary embolectomy using the FlowTriever Retrieval/Aspiration System. JVIR 2017;28(4):621-3.||Case Report|
|4||Tukaye DN, McDaniel M, Liberman H, et al. Percutaneous pulmonary embolus mechanical thrombectomy. JACC 2017;10(1):94-5.||Case Report|
|5||Engelhardt TC. Rapid removal of pulmonary emboli and subsequent reversal of right ventricular dysfunction using the FlowTriever Retrieval/Aspiration System. CathLabDigest Feb 2017;25(2).||Case Report|
|6||Ishola A, Ahmad US, Voelkel AJ, et al. Retrieve to relieve: Novel percutaneous thrombectomy device in selected patients with pulmonary embolism. CathLab Digest; Volume 25, Issue 5, May 2017.||Single-center Case Series|
|7||Nosher et al. Endovascular treatment of pulmonary embolism: Selective review of available techniques. World Journal of Radiology. December 28, 2017.||Technical Review|
|8||Beasley R, Marston W, Annambhotla S, Jaber WA. Emerging Tools for Lytic-Free, Single-Session Treatment of Venous Thromboembolic Disease. Insert to Endovascular Today, August 2018, Vol. 17, No. 8.||Case Report|
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|10||Devcic Z and Kou W. Percutaneous pulmonary embolism thrombectomy and thrombolysis: Technical tips and tricks. Semin Intervention Radio, 2018; 35:129-135||Technical Review|
|11||Basman C, Rashid U, Parmar YJ, et al. The role of percutaneous vacuum-assisted thrombectomy for intracardiac and intravascular pathology. J Card Surg. 2018;33(10):666-672.||Review|
|12||Improving the Risk/Benefit Profile for Managing VTE With Lytic-Free Mechanical Thrombectomy, Insert to Endovascular Today, March 2019, Vol. 18, No. 3.||Case Report|
|13||Avgerinos E et al. Catheter-director thrombolysis versus suction thrombectomy in the management of acute pulmonary embolism. J Vasc Surg: Venous and Lym Dis 2019; 1-6.||Clinical Study|
|14||Yale School of Medicine: New Treatment to Remove Clots Offers Dramatic Results, March 14, 2019||Hospital Newsletter|
|15||Tu T, Toma C, Tapson VF, et al. A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism: The FLARE Study. JACC Cardiovasc Interv. 2019;12(9):859-869.||510k Clinical Trial|
|16||Tu, Maldonado, Annambhotla: Common but complex venous cases, EVT publication, July||Case Series|
|17||Rivera-Lebron et al. Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium. Clinical and Applied Thrombosis/Hemostasis (25): 1-16. June 2019.||Review|
|18||Wible, Buckley, Cho, Bunte, Saucier, and Borsa. Safety and Efficacy of Acute Pulmonary Embolism Treated via Large-Bore Aspiration Mechanical Thrombectomy Using the Inari FlowTriever Device. J Vasc Interv Radiol 2019; 1–6.||Retrospective Single-center Study|
|19||Giri, Sista, Weinberg, et al. Interventional Therapies for Acute Pulmonary Embolism: Current Status and Principles for the Development of Novel Evidence. A Scientific Statement from the American Heart Association. Circulation 2019. ; 140:00-00.||Review|
|20||Kishore and Dillon - Is It Time to End the Therapeutic Nihilism Toward Treating VTE in Cancer Patients? EVT October issue||Case Series|
|21||Nezami et al., Right Atrial and Massive Pulmonary Artery Mechanical Thrombectomy Under Echocardiography Guidance Using the FlowTriever System EJVES short reports https://doi.org/10.1016/j.ejvssr.2019.10.001||Case Report|
|22||Salimnia and Qaqi A Patient With Spontaneous Pulmonary Embolism and Concomitant Deep Vein Thrombosis Treated With FlowTriever and ClotTriever Mechanical Thrombectomy
VASCULAR DISEASE MANAGEMENT 2019;16(11):E161-E164.
|23||Sharp and Attallah, Future perspectives in catheter-based treatment of pulmonary embolism
European Heart Journal Supplements (2019) 21 (Supplement I), I31–I37