Decorative Graphic
Important Notice
This Inari Medical website and all product offerings listed are tailored for the United States only. Please be aware that product availability and regulatory claims may vary in other regions we serve, including Europe, the Middle East, and Africa (EMEA), Asia-Pacific (APAC), and Latin America/Canada. Inari Medical is currently developing separate websites for our products tailored to these other global and regional markets.
Decorative Graphic
Randomized controlled trial (RCT) of
FlowTriever® vs. anticoagulation alone
in acute pulmonary embolism (PE)
PEERLESS II Study
NCT06055920
Up to 1200 Patients
Randomized 1:1
  • Prospective, international, randomized controlled trial of FlowTriever thrombectomy versus anticoagulation alone in intermediate-risk PE
  • Up to 1200 patients (1:1 FlowTriever vs. anticoagulation alone) at up to 100 global sites
Primary Endpoint
Win Ratio composite
  • All-cause mortality by 30 days
  • Clinical deterioration through
    discharge or up to 30 days
  • All-cause hospital readmission
    by 30 days
  • Bailout therapy through
    discharge or up to 30 days
  • Dyspnea at 48-hour visit
Follow-Up
  • Patients are assessed at 48-hour visit, discharge, 1-month visit, and 3-month visit
Intermediate-Risk PE with Additional Clinical Risk Factors
Up to 1200 patients randomized 1:1
FlowTriever Arm
AC Arm
Peerless II Flowchart
Randomization (+/- Index Procedure) > 48-Hour Visit
> Hospital Discharge > 1 Month Visit > 3 Month Visit
Indications for Use:
The FlowTriever retrieval/aspiration system is indicated for (1) the non-surgical removal of emboli and thrombi from blood vessels and (2) injection, infusion and/or aspiration of contrast media and other fluids into or from a blood vessel. The FlowTriever retrieval/aspiration system is intended for use in the peripheral vasculature and for the treatment of pulmonary embolism. Triever catheters are indicated for (1) the non-surgical removal of emboli and thrombi from blood vessels and (2) injection, infusion and/or aspiration of contrast media and other fluids into or from a blood vessel. Triever catheters are intended for use in the peripheral vasculature and for the treatment of pulmonary embolism. The Triever catheters are also intended for use in treating clot in transit in the right atrium but not in conjunction with the FlowTriever catheters.

Refer to IFU for complete Indications for Use, contraindications, warnings, and precautions.

Caution:
Federal (USA) law restricts this device to sale distribution and use by or on order of a physician.

All trademarks are property of their respective owners.