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What is Venous
Thromboembolism
(VTE)?
VTE is a term referring to blood clots in the veins, is an underdiagnosed and serious medical condition
that affects nearly 900,000 Americans each year.1

When a venous blood clot forms, it can limit or completely block the flow of blood within the body. There are two types of clots that together are known as VTE: Deep Vein Thrombosis and Pulmonary Embolism.
What is Venous Thromboembolism?
Deep Vein Thrombosis (DVT)
What is it?
A DVT occurs when a blood clot, or thrombus, forms in one or more of the deep veins in the body, usually in the lower legs, thigh, or pelvis. In some cases, DVT can occur in other areas, such as the arms.
Why is it dangerous?
The formation of a clot can damage valves and walls of veins. If clot remains in the veins for a long period of time, this can result in long-term consequences known as postthrombotic syndrome (PTS). PTS impacts up to 50% of DVT2 patients with life-debilitating symptoms such as severe pain, swelling and discoloration of the affected limb.
Pulmonary Embolism (PE)
What is it?
A serious complication of DVT that occurs when part of a blood clot breaks off and travels through the bloodstream to the pulmonary arteries.
Why is it dangerous?
A PE blocks blood flow to the lungs, causing increased stress on the heart and decreased oxygen levels in the body. As the heart works harder to pump blood past the clot, it can become enlarged, with greater risk of failure. PE is the third leading cause of cardiovascular death in the US after heart attack and stroke.
WHAT ARE THE
WARNING SIGNS
AND SYMPTOMS
OF VTE?
VTE can occur without any warning, but there are several important signs and symptoms to know. Recognizing these signs and symptoms can save a life. See your doctor as soon as possible if you have any symptoms of a blood clot.
Pulmonary Embolism (PE):
Deep Vein Thrombosis (DVT):
  • Unexplained shortness of breath
  • Rapid breathing
  • Chest pain (maybe worse upon deep breath)
  • Rapid heart rate
  • Light headedness or passing out
  • Pain or tenderness, often starting in the calf
  • Swelling, including the ankle or foot
  • Redness or noticeable discoloration
  • Warmth
WHAT ARE THE RISK
FACTORS FOR VTE?
Everyone is at risk of developing VTE, however, your risk can be increased by several factors, including:
HOW IS VTE DIAGNOSED?
There are several ways that VTE can be diagnosed.
DVT
  • Duplex venous ultrasound
  • Venogram
  • Magnetic resonance imaging (MRI)
PE
  • Computed tomography angiography (CTA)
  • Blood tests
  • Ventilation-perfusion (V/Q Scan)
  • Pulmonary angiogram
WHAT ARE THE TREATMENT
OPTIONS FOR VTE?
There are different ways to treat VTE, including drugs and a minimally invasive procedure known as mechanical thrombectomy.
Anticoagulation Drugs
(Blood thinners)
The majority of VTE patients are treated with anticoagulation or blood thinners alone. Anticoagulation may reduce the formation of a new clot but cannot dissolve or break down existing clot.
Thrombolytic Drugs
(Clot-busters)
These drugs work to dissolve blood clots to restore blood flow. While clot-busters may work on newer clots, they become less effective the longer the clot has been in the body. This treatment is also linked with a higher risk of bleeding, which can be deadly and requires a stay in the intensive care unit (ICU).
Mechanical thrombectomy
(DVT & PE)
DVT: Minimally invasive, mechanical thrombectomy with the ClotTriever system physically removes the clots from the body and restores blood flow to the affected area. Many patients experience immediate symptom relief and are able to return to normal activity shortly after the procedure.
Learn more about the ClotTriever® system for the treatment of DVT
PE: Minimally invasive, mechanical thrombectomy with the FlowTriever system aspirates the clots from the pulmonary arteries and often provides patients with immediate symptom relief. Treatment of PE with the FlowTriever system does not require thrombolytics, so many patients can go home shortly after their procedure.
Learn more about the FlowTriever® system for the treatment of DVT
The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment.

References
1. https://www.cdc.gov/ncbddd/dvt/infographic-impact.html
2. Kahn SR. The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the American Heart Association. Circulation. 2014 Oct 28;130(18):1636-61

FlowTriever indications for use:
The FlowTriever Retrieval/Aspiration System is indicated for: (1) The non-surgical removal of emboli and thrombi from blood vessels. (2) Injection, infusion, and/or aspiration of contrast media and other fluids into or from a blood vessel. The FlowTriever Retrieval/Aspiration System is intended for use in the peripheral vasculature and for the treatment of pulmonary embolism.

CONTRAINDICATIONS
  • Not intended for use in the cerebral, carotid, or coronary arteries
  • Not intended for use in endarterectomy procedures or vessel dilation
  • Not indicated for the removal of fibrous, adherent, or calcified material (e.g., atherosclerotic plaque)
  • Not intended for use in vessels < 6 mm
  • Not intended for use with power injector

WARNINGS
  • Intended for single use only. Do not re-sterilize or reuse this device. Reprocessing and re-sterilizatio increase the risks of patient infection and compromised device performance.
  • Should be used in conjunction with fluoroscopic guidance and proper anticoagulation agents
  • Examine the devices before use to verify they are not damaged
  • Use before the "Use By" date specified on the product packaging
  • Excess pressure may result in catheter damage or patient injury
  • Avoid using excessive force to advance or retract against resistance. If excessive resistance occurs, retrac and collapse the distal disks into the catheter and remove the device. Excessive force against resistance may result in damage to the device or vessel perforation.
  • In the event of patient deterioration, remove FlowTriever Catheter/Triever Catheter and assess situation
  • Ensure that FlowTriever wireform disks are withdrawn into Triever Guide Catheter prior to removal fro patient to avoid vascular damage.
  • Do not use in blood vessels that have a history of therapeutic irradiation. Vessel perforation may occur

ClotTriever indications for use:
The ClotTriever Thrombectomy System consists of the ClotTriever Catheter and ClotTriever Sheath. The ClotTriever Thrombectomy System is indicated for: (1) The non-surgical removal of thrombi and emboli from blood vessels. (2) Injection, infusion, and/or aspiration of contrast media and other fluids into or from a blood vessel. The ClotTriever Thrombectomy System is intended for use in the peripheral vasculature including deep vein thrombosis (DVT).

CONTRAINDICATIONS:
  • Not intended for use without anticoagulation.
  • Not intended for use in the cerebral, carotid or coronary vasculature.
  • Not intended for use in the pulmonary arteries.
  • Not intended for use in endarterectomy procedures or vessel dilation.
  • Not indicated for the removal of fibrous, adherent or calcified material (e.g., atherosclerotic plaque).
  • Not intended for use in vessels < 6 mm.
  • Not intended for use with power injectors.

WARNINGS
  • When used in patients with an IVC filter, damage to the filter, the collection bag, or dislodgment of the VC filter, etc. may occur.
  • When the ClotTriever device is in the path of an exposed stent, damage to the stent, the collection bag, or dislodgment of the stent, etc. may occur.
  • Intended for single use only. Do not re-sterilize or reuse this device. Reprocessing and re-sterilization increase the risks of patient infection and compromised device performance.
  • Should be used in conjunction with fluoroscopic guidance and proper anticoagulation agents.
  • Examine the ClotTriever Catheter prior to insertion to verify it is not damaged.
  • Use before the "Use By" date specified on the product packaging.
  • Avoid using excessive force to advance or retract against resistance. If excessive resistance is encountered, retract and collapse the collection bag and coring element into the Outer Catheter
    • and remove the device. Excessive force against resistance may result in damage to the device or vessel.
  • In the event of patient deterioration, remove the ClotTriever System.
  • Ensure that ClotTriever Catheter is withdrawn into the ClotTriever Sheath prior to removal from patient to avoid vascular damage