550 Patients in RCT: 1:1

Enrolling up to 700 patients total, including a non-randomized cohort of up to 150 patients with absolute contraindication to thrombolytics.

Primary Endpoint

Win Ratio composite at discharge (7d max):

1. All-cause mortality
2. Intracranial hemorrhage
3. ISTH major bleeding
4. Clinical deterioration and/or bailout
5. ICU admission and ICU LOS